In principle, NIH staff collaborates with PD/PI and supports and supports research as a partner. Staff must not play a dominant role or assume primary direction or responsibility for the activities of the recipients. NIDDK does not accept applications for multi-center clinical trials. which are submitted as R01, with the exception of studies complementary to existing cooperation agreements, which may be submitted as R01s to ongoing major clinical studies to promote areas of scientific interest within the NIDDK (R01) PAR-18-042 mission, or applications submitted in response to other or future UNFSOs that specifically invite multi-center studies. This directive does not apply to pilot studies. Investigators interested in interested pilot studies may use the R21 mechanism. An executive agency uses a grant agreement as a legal instrument that reflects a relationship between the U.S. government and a state, local government or other recipient when – the primary goal of these young researchers is to establish themselves and their teams as experts in their field of research. First consider why the Institute uses a cooperation agreement instead of an R-Series grant and what it means to you as a PD/PI. A cooperation agreement is a support mechanism that the NIH often uses for high-priority research areas that require a higher level of NIH staff participation than a typical research project (R). This essential participation is normally necessary for monitoring, coordination or facilitation; Below, we explain that in more detail the concept of “essential personal interest.” Resource-based research projects – Cooperation Agreements (U24) support research projects that contribute to improving the resource capacity of biomedical research. Since cooperation agreements are generally used for complex or targeted projects requiring close coordination of several grants or resources, you need to go through the FOA in depth and take into account the experience, intensity and degree of cooperation required to manage the cooperation agreement. Given the nature of the cooperation agreements, you can expect NIAID staff to work more closely with you and program more frequent communications than for a PD/PI scholarship.